منابع مشابه
Endothelin antagonists in subarachnoid hemorrhage: what next?
In the previous issue of Critical Care, Ma and colleagues perform a meta-analysis of five randomized, clinical trials of endothelin antagonists in patients with aneurysmal subarachnoid hemorrhage. There are four trials using clazosentan and one trial with TAK-044. These studies show that endothelin plays an important role in the genesis of angiographic vasospasm. The benefit of these drugs is l...
متن کاملEndothelin B Receptor Antagonists Attenuate Subarachnoid Hemorrhage
Cerebral Vasospasm Induced − Endothelin B Receptor Antagonists Attenuate Subarachnoid Hemorrhage Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.29.9.1924 1998;29:1924-1929 Stroke. http://stroke.ahajournals.org/c...
متن کاملAbsence of elevation of big endothelin in subarachnoid hemorrhage.
BACKGROUND AND PURPOSE Endothelin peptides are potent vasoconstrictors and thus are seen as potential cause of cerebral vasospasm after subarachnoid hemorrhage (SAH). Earlier reports showed elevated or normal endothelin levels in plasma and cerebrospinal fluid in patients suffering from SAH. The present study was designed to determine whether endothelin is a causal factor in SAH. METHODS We s...
متن کاملCardiac Complication Following Subarachnoid Hemorrhage
Besides its severe neurological injuries, spontaneous subarachnoid hemorrhage (SAH) commonly causes cardiac complications. These complications could include three different aspects of cardiac diseases, that is, electrocardiographic abnormalities, myocardial injuries, and left ventricular dysfunction. These complications not only may lead to misdiagnosis of SAH as myocardial infarction, but also...
متن کاملEndothelin B receptor antagonists attenuate subarachnoid hemorrhage-induced cerebral vasospasm.
BACKGROUND AND PURPOSE While it has been widely reported that the vasospasm following subarachnoid hemorrhage (SAH) is prevented/reversed by endothelin (ET) receptor antagonists selective for the ET(A) receptor and by nonselective ET receptor antagonists, ie, antagonists of both the ET(A) and ET(B) receptors, there are no reports on the possible attenuation of the spasm by selective ET(B) recep...
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ژورنال
عنوان ژورنال: Stroke
سال: 2000
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.31.12.2971